| Product Name | Anti-KLK3 (AT1D10) |
|---|---|
| Description | Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. PSA is now used to indicate the presence of semen in forensic serology. The semen of adult males has PSA levels far in excess of those found in other tissues; therefore, a high level of PSA found in a sample is an indicator that semen may be present. Because PSA is a biomarker that is expressed independently of spermatozoa, it remains useful in identifying semen from vasectomized and azoospermic males. |
| Synonyms | Prostate-specific antigen, APS, hK3, KLK2A1, PSA |
| Host | Mouse |
| Clone | AT1D10. Anti-human KLK3 mAb, clone AT1D10, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human KLK3 protein. |
| Immunogen | Recombinant human KLK3(25-261aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Balk SP, Ko YJ, Bubley GJ (January 2003). J. Clin. Oncol. 21 (2): 383€“91.Lilja H (November 2003). Urology 62 (5 Suppl 1): 27€“33.Rao AR, Motiwala HG, Karim OM (January 2008). BJU Int. 101 (1): 5€“10. |
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