| Product Name | Anti-Mucin 1 Monoclonal Antibody |
|---|---|
| Description | This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants. The human Mucin 1 antibody is reactive with 90% of breast carcinoma, most epithelial ovarian carcinoma and a high portion of the lung, urogenital and gastrointestinal carcinomas. Some reactivity is observed in the apical membrane of normal breast epithelium. Weak reactivity is also present in pancreas, kidney and lung. |
| Synonyms | EMA, PEM, PUM, KL-6, MAM6, PEMT, CD227, H23AG, MCKD1, MUC-1, CA 15-3, MUC-1/X, MUC1/ZD, MUC-1/SEC |
| Clone | BC-2 |
| Immunogen | Human milk fat globuline membrane preparation |
| Isotype | IgG1 |
| Specificity | BC-2 reacts with a five amino acid epitope of the MUC-1 core protein, which is less affective for glycosilation than most other MUC-1 epitopes. Localization: cytoplasm and membrane. |
| Reactivity | Human |
| Applications | IHC, WB |
| Form | Purified Ig |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Xing, XP. et al.(1989) Immunol. Cell Biol 67: 183-195McGuckin, MA et al. (1996) British J. of Cancer 73: 85-88 |
| Supplier | ARP |
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