| Product Name | Anti-NANS (clone AT1G6) |
|---|---|
| Description | NANS(Sialic acids synthease) is an enzyme that functions in the biosynthetic pathways of sialic acids. Expressed ubiquitously, NANS enzymatically catalyzes the H2O-dependent formation of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), both of which are sialic acids. NANS uses N-acetylmannosamine 6-phosphate as a substrate for Neu5Ac synthesis and mannose 6-phosphate as a substrate for KDN synthesis. |
| Synonyms | Sialic acid synthase, SAS, N acetylneuraminate synthase |
| Host | Mouse |
| Clone | AT1G6. Anti-human NANS mAb, clone AT1G6, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NANS protein. |
| Immunogen | Recombinant human NANS (1-359aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Milstein O., et al. (2008) J Biol Chem. 283(49):34414-22.Aldape MJ., et al. (2007) J Infect Dis. 195(12):1838-45. |
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