Anti-p27Kip1 (Mitotic Inhibitor/Suppressor Protein), Monoclonal Antibody
| Product Name | Anti-p27Kip1 (Mitotic Inhibitor/Suppressor Protein), Monoclonal Antibody |
|---|---|
| Description | Recognizes a 27kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. Its epitope spans between aa 83-204 of p27. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. p27Kip1 functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. This monoclonal antibody co-precipitates cdk4 in complex p27Kip1 and is excellent for staining of formalin-fixed tissues. |
| Synonyms | CDKN1B, CDKN4, Cyclin Dependent Kinase Inhibitor 1B, Cyclin-dependent kinase inhibitor p27 Kip1, KIP1, MEN1B, MEN4 |
| Host | Mouse |
| Clone | DCS-72.F6 + KIP1/769 |
| Immunogen | Mouse recombinant p27 protein (DCS-72.F6); Recombinant human CDKN1B protein (KIP1/769) |
| Isotype | IgG's |
| Reactivity | Human, Mouse, Primate, Rat |
| Applications | FC, IF, IHC, WB |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 1027 |
| Uniprot | P46527 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Fredersdorf S et. al. Proc Natl Acad Sci 1997;94:6380-5 |
| Supplier | ARP |
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