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|Product Name||Anti-PARP2 (clone AT29G4)|
|Description||PARP2 is poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.|
|Applications||Dot blot, ELISA, WB|
|Clone||AT29G4. Anti-human PARP2 mAb, clone AT29G4, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PARP2 protein.|
|Form||Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide.|
|Immunogen||Recombinant human PARP2 (233-583aa) purified from E. coli|
|References||Ame JC, Rolli V, Schreiber V et al. (1999). J. Biol. Chem. 274 (25): 178608.Schreiber V, Amé JC, Dollé P et al. (2002). J. Biol. Chem. 277 (25): 2302836.Maeda Y, Hunter TC, Loudy DE et al. (2006). J. Biol. Chem. 281 (14): 96006.|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Poly (ADP-ribose) polymerase 2, ADPRT2, ADPRTL2, ADPRTL3, ARTD2, pADPRT-2, PARP-2|
|Working Dilutions||Optimal dilution should be performed by user.|
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