| Product Name | Anti-Plakophilin 1 Monoclonal Antibody |
|---|---|
| Description | This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. Mouse Monoclonal Antibody to Plakophilin 1. Plakophilin 1: calculated mol. wt. 80,496 (human) and 80,180 (bovine) |
| Synonyms | B6P, PKP1 |
| Clone | PP1-5C2 |
| Immunogen | Plakophilin 1 (band 6 polypeptide of bovine muzzle epidermis) |
| Isotype | IgG1 |
| Specificity | Antibody recognizes plakophilin 1 in diverse stratified epithelia, in complex epithelia (e.g. urothelium of the bladder and tracheal epithelium) and in glandular duct epithelia; squamous cell carcinoma are positive, whereas all adenocarcinoma tested so far are negative. |
| Reactivity | Amphibian, Bovine, Human, Porcine |
| Applications | IHC, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | 1. Heid, H.et al. (1994) Differentiation 58: 22. Schmidt, A. et al. (1994) Eur. J. Cell Biol. 65: 229-2453. SchÌÄå_fer, S. et al. (1996) Differentiation 60: 99-1084. Moll, I. Et al. (1997) J. Invest. Derm. 108: 139-1415. Akat K et al. (2003) Acta Neuropathol 106: 337-347 |
| Supplier | ARP |
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