Anti-Plectin Polyclonal Antibody

Category: Antibodies
Catalog
03-GP21
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Product Name Anti-Plectin Polyclonal Antibody
Description Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes
Synonyms PLEC, HD1, PCN, EBS1, EBSO, PLTN, PLEC1, LGMD2Q, PLEC1b
Immunogen C-terminal C domain of human recomb. Plectin (aa 4367 - 4684),Stabilized Serum,Human; strong cross-reactivity with Bovine, Mouse Xenopus laevis, Fish
Specificity Suitable for Frozen & Paraffin sections, Cytological material, Immunoblotting (Western)
Form Calculated MW 532,000 protein plectin, localizing to plasma membrane attachment sites of intermediate filaments and microfilaments (actin) such as desmosomes and hemi-desmosomes, Z-line structures and dense plaques of striated and smooth muscle. Strong positive reaction is also found with endothelia, fibroblasts and infiltrating cells (e.g. lymphocytes). Human Glia cells are specifically detected.
Supplier ARP

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