Anti-S Polyclonal Antibody

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Product Name Anti-S Polyclonal Antibody
Description S1 attaches the virion to the cell membrane by interacting with sialic acid-containing cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Background S1 attaches the virion to the cell membrane by interacting with sialic acid-containing cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Host Rabbit
Isotype IgG
Immunogen Recombinant Human coronavirus OC43 Spike glycoprotein (15-344AA)
Reactivity Virus
Applications ELISA, Dot Blot
Form Liquid, in 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4
Storage Store at -20C or -80C. Avoid repeated freeze/thaw cycles.
Intended Use For Research Use Only

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