Anti-SOCS1 Polyclonal Antibody

Antibodies, Polyclonal Antibodies, Cusabio
More Information
Product Name Anti-SOCS1 Polyclonal Antibody
Background SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival By similarity. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Host Rabbit
Isotype IgG
Immunogen Recombinant human Suppressor of cytokine signaling 1 protein (1-211AA)
Reactivity Human
Applications ELISA, IHC
Form Liquid, in 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4
Uniprot O15524
Storage Store at -20C or -80C. Avoid repeated freeze/thaw cycles.
Intended Use For Research Use Only

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