Anti-Thyroglobulin (Thyroidal Cell Marker), Monoclonal Antibody
| Product Name | Anti-Thyroglobulin (Thyroidal Cell Marker), Monoclonal Antibody |
|---|---|
| Description | Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. _Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. _The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms. |
| Synonyms | AITD3, hTG, TDH3, Tg, Tgn |
| Host | Mouse |
| Clone | 6E1. |
| Immunogen | Human thyroid follicular cells |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 7038 |
| Uniprot | P01266 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References |
Ossendorp FA, et. al. Journal of Immunological Methods, 1989, 120(2):191-200. Bellet, D, et al. J Clin Endocrin Metab 1983;56:530-533 Heffess CS et al. Cancer. 2002;95(9):1869-78 Judkins AR et al. Hum Pathol. 1999;30(11):1373-6 |
| Supplier | ARP |
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