ATPIF1, 26-106aa, Human

Proteins, Recombinant
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Product Name ATPIF1, 26-106aa, Human
Applications SDS-PAGE
Background ATPase inhibitory factor 1, also known as ATPIF1, binds to the C-terminal region of a beta subunit of the F1-ATPase at low pH values and, via interference of the beta and gamma subunit interaction, ATPIF1 regulates the activity of the F1 (the hydrophilic catalytic core), F0 (the membrane embedded protein channel) ATPase. The overexpression of ATPIF1 in several human carcinomas further supports its participation in oncogenesis and provides insight into the altered metabolism of cancer cells, which includes the reprogramming of energetic metabolism toward glycolysis. Recombinant human ATPIF1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 0.5mg/ml (determined by Bradford assay)
Form Liquid, in 20 mM Tris-HCl buffer, pH7.5, 10% glycerol, 1mM DTT, 200mM NaCl
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 63.6kDa (586aa)
NCBI Accession # NP_057395
Purity > 95% by SDS-PAGE
References Sanchez Cenizo L., et al. (2010) J Biol Chem. 285: 25308-13.
Cortes Hernandez P., et al. (2005) Biochem Biophys Res Commun. 330: 844-849.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms ATPase inhibitor mitochondrial, ATPI, ATPIP, IP, ATPase Inhibitory Factor 1
Tag His-tag

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