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|Product Name||BAALC, 1-145aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGCGGSRADA IEPRYYESWT RETESTWLTY TDSDAPPSAA APDSGPEAGG LHSGMLEDGL PSNGVPRSTA PGGIPNPEKK TNCETQCPNP QSLSSGPLTQ KQNGLQTTEA KRDAKRMPAK EVTINVTDSI QQMDRSRRIT KNCVN|
|Background||Brain and acute leukemia, cytoplasmic (BAALC) is localizes to both the membrane and the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed by hematopoetic and neural cells, BAALC interacts with CaMKIIalpha and is thought to play a role in synaptic function at postsynaptic lipid rafts. Overexpression of BAALC concomitant predict adverse clinical outcome and may define important risk factor in cytogenetically normal acute myeloid leukemia (AML). Recombinant human BAALC, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 50mM NaCl, 10% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||36.5 kDa (325aa), confirmed by MALDI-TOF.|
|NCBI Accession #||NP_079088|
|Purity||> 95% by SDS-PAGE|
|References||Tanner SM., et al. (2001) Proc Natl Acad Sci U S A. 98(24):13901-6.
Satoskar AA., et al. (2005) Gene Expr Patterns. 5(4):463-73.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||, Brain and acute leukemia, cytoplasmic isoform 1 Brain and acute leukemia cytoplasmic, FLJ12015.|
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