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|Product Name||BAG1, 1-230aa, Human|
|Background||BCL2-associated athanogene, also known as BAG1, is a member of the Bcl-2 family of proteins that play varied stimulatory or inhibitory roles in the regulation of programmed cell death. This functions in conjunction with Bcl-2 to inhibit apoptosis. Also, BAG1 has been implicated in age related neurodegenerative diseases as Alzheimer's. It is localized to the cytosol, nucleus or both. Recombinant human BAG1 was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||HAP, RAP46, BCL2-associated athanogene 1 Bag 1, BAG family molecular chaperone regulator 1, BCL 2 associated athanogene, BCL 2 Associated Athanogene 1, BCL 2 binding athanogene 1, BCL2 associated athanogene, BCL2 associated athanogene 1, Glucocorticoid receptor-associated protein RAP46, HAP1, Haptoglobin, RAP 46.|
|AA Sequence||MNRSQEVTRD EESTRSEEVT REEMAAAGLT VTVTHSNEKH DLHVTSQQGS SEPVVQDLAQ VVEEVIGVPQ SFQKLIFKGK SLKEMETPLS ALGIQDGCRV MLIGKKNSPQ EEVELKKLKH LEKSVEKIAD QLEELNKELT GIQQGFLPKD LQAEALCKLD RRVKATIEQF MKILEEIDTL ILPENFKDSR LKRKGLVKKV QAFLAECDTV EQNICQETER LQSTNFALAE|
|Molecular Weight||29.5 kDa (260aa), confirmed by MALDI-TOF.|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT|
|Concentration||1.0 mg/ml (determined by Bradford assay)|
|Purity||> 90% by SDS-PAGE|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Wang HG., et al. (1996) Proc Natl Acad Sci U S A. 93(14):7063-8.
Takayama S., et al. (1995) Cell. 80(2):279-84.
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