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|Product Name||BAG2, 1-211aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK TLQQNAESRF N|
|Background||BCL2-associated athanogene 2, also known as BAG2, is a member of the Bag family of proteins. BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain. BAG2 is a major component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex and acts to disrupt CHIP-mediated ubiquitylation. Recombinant human BAG2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 7.5) containing 2mM DTT, 10% glycerol, 50mM NaCl|
|Intended Use||For Research Use Only|
|Molecular Weight||10.8 kDa (94aa) confirmed by MALDI-TOF|
|NCBI Accession #||NP_004273|
|Purity||> 95% by SDS-PAGE|
|References||Takayama S., et al. (1999) J Biol Chem. 274:781-786.
Arndt V., et al. (2005) CHIP Mol Biol Cell. 16:5891-5900.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||BCL2-associated athanogene 2, BAG-2|
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