BAG2, 1-211aa, Human

Proteins, Recombinant
More Information
Product Name BAG2, 1-211aa, Human
Background BCL2-associated athanogene 2, also known as BAG2, is a member of the Bag family of proteins. BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain. BAG2 is a major component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex and acts to disrupt CHIP-mediated ubiquitylation. Recombinant human BAG2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Species Human
Synonyms BCL2-associated athanogene 2, BAG-2
Host E.coli
Tag His-tag
Molecular Weight 10.8 kDa (94aa) confirmed by MALDI-TOF
Form Liquid, in 20mM Tris-HCl buffer (pH 7.5) containing 2mM DTT, 10% glycerol, 50mM NaCl
Concentration 0.5 mg/ml (determined by Bradford assay)
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI NP_004273
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Takayama S., et al. (1999) J Biol Chem. 274:781-786.
Arndt V., et al. (2005) CHIP Mol Biol Cell. 16:5891-5900.

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