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|Product Name||CARHSP1, 1-147aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MSSEPPPPPQ PPTHQASVGL LDTPRSRERS PSPLRGNVVP SPLPTRRTRT FSATVRASQG PVYKGVCKCF CRSKGHGFIT PADGGPDIFL HISDVEGEYV PVEGDEVTYK MCSIPPKNEK LQAVEVVITH LAPGTKHETW SGHVISS|
|Background||CRAHSP1 is a serine phosphoprotein originally identified as a physiological substrate for the Ca2+-calmodulin regulated protein phosphatase calcineurin (PP2B). This protein interacts with the STYX/dead phosphate protein in developing spermatids and is a paralog of the brain-specific mRNA-binding protein PIPPIN. It is thought to play a common role in calcium-mediated signal transduction resulting from phosphorylation on serine residues. Recombinant human CRAHSP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1mM DTT, 0.1M NaCl, 1mM EDTA.|
|Intended Use||For Research Use Only|
|Molecular Weight||24.1 kDa (215aa), confirmed by MALDI-TOF|
|NCBI Accession #||NP_055131|
|Purity||> 90% by SDS-PAGE|
|References||Schäfer C., et al. (2003) Am J Physiol Gastrointest Liver Physiol.. 285:G726-34
Groblewski G.E, et al. (1998) J. Biol. Chem. 273: 22738-22744.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||CRHSP-24, CSDC1, MGC111446, Calcium-regulated heat stable protein 1|
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