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|Product Name||CD8B, 22-170aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSLQQTPAY IKVQTNKMVM LSCEAKISLS NMRIYWLRQR QAPSSDSHHE FLALWDSAKG TIHGEEVEQE KIAVFRDASR FILNLTSVKP EDSGIYFCMI VGSPELTFGK GTQLSVVDFL PTTAQPTKKS TLKKRVCRLP RPETQKGPLC SP|
|Background||CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Recombinant human CD8B protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 50% glycerol.|
|Intended Use||For Research Use Only|
|Molecular Weight||10.8 kDa (101aa), confirmed by MALDI-TOF
(Molecular size on SDS-PAGE will appear higher)
|NCBI Accession #||NP_004922|
|Purity||> 80% by SDS-PAGE|
|References||Heigele,A, et al. (2012) J. Virol. 86 (1), 36-48
Laugel,B., et al. (2011) J. Leukoc. Biol. 90 (6), 1089-1099
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||T-cell surface glycoprotein CD8 beta chain isoform 5 precursor, CD8B1, LEU2, LY3, LYT3, P37|
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