CDK2AP1, 1-115aa, Human

Proteins, Recombinant
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Product Name CDK2AP1, 1-115aa, Human
Applications SDS-PAGE
Background CDK2AP1 is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. Also, interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes. Recombinant CDK2AP1 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 44.8 kDa (396aa), confirmed by MALDI-TOF.
NCBI Accession # NP_004633
Purity > 95% by SDS-PAGE
References Tsuji T., et al. (1998) J Biol Chem. 273(12):6704-9.
Hu MG., et al. (2004) Cancer Res. 64(2):490-9.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms CDKAP1, DOC1, CDKA1, Cyclin-dependent kinase 2 associated protein 1 CDK2 A1, CDK2 associated protein 1, CDK2AP1, Cyclin dependent kinase 2 associated protein 1 Deleted in oral cancer 1, DOC 1, DOC 1 related protein, DOC 1R, DOC1R, Putative oral cancer suppressor.
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