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|Product Name||CGB, 21-165aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSSKEPLRP RCRPINATLA VEKEGCPVCI TVNTTICAGY CPTMTRVLQG VLPALPQVVC NYRDVRFESI RLPGCPRGVN PVVSYAVALS CQCALCRRST TDCGGPKDHP LTCDDPRFQD SSSSKAPPPS LPSPSRLPGP SDTPILPQ|
|Background||CGB is a member of the glycoprotein hormone beta chain family and is the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. Recombinant human CGB protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||27.8 kDa (243aa)|
|NCBI Accession #||NP_000728|
|Purity||> 85% by SDS-PAGE|
|References||Andrusiewicz M, Szczerba A, et al. (2011). J Transl Med. 9:130.
Gregor CR, Cerasoli E, et al. (2011). J Biol Chem. 286(28):25016-26.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Choriogonadotropin subunit beta precursor, CGB3, CGB5, CGB7, CGB8, Hcgb|
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