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|Product Name||CHCHD3, 1-227aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMGGTTST RRVTFEADEN ENITVVKGIR LSENVIDRMK ESSPSGSKSQ RYSGAYGASV SDEELKRRVA
EELALEQAKK ESEDQKRLKQ AKELDRERAA ANEQLTRAIL RERICSEEER AKAKHLARQL EEKDRVLKKQ DAFYKEQLAR LEERSSEFYR
VTTEQYQKAA EEVEAKFKRY ESHPVCADLQ AKILQCYREN THQTLKCSAL ATQYMHCVNH AKQSMLEKGG
|Background||Coiled-coil-helix-coiled-coil-helix domain containing protein 3, also known as CHCHD3, is required for maintenance of mitochondrial crista integrity and mitochondrial function. This protein may act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. It has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Recombinant human CHCHD3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||0.25mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl (pH 8.0) containing 20% glycerol, 0.15M NaCl, 1mM DTT|
|Intended Use||For Research Use Only|
|Molecular Weight||14.6 kDa (128aa) confirmed by MALDI-TOF|
|NCBI Accession #||NP_060282|
|Purity||> 80% by SDS-PAGE|
|References||Liu H., et al. (2012) PLoS ONE. 7:E34832-E34832
Alkhaja A.K., et al. (2012) Mol. Biol. Cell. 23:247-257
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
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