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|Product Name||CHP, 1-195aa, Human|
|Background||CHP (Calcium-binding protein P22) is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity. Recombinant human CHP, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Synonyms||SLC9A1BP, Calcineurin B homolog, Calcineurin homologous protein, Calcium-binding protein p22, Calcium binding protein CHP, Sid 470, Sid470, SLC9A1 binding protein, Wrch2|
|AA Sequence||MGSSHHHHHH SSGLVPRGSH MMGSRASTLL RDEELEEIKK ETGFSHSQIT RLYSRFTSLD KGENGTLSRE DFQRIPELAI NPLGDRIINA FFPEGEDQVN FRGFMRTLAH FRPIEDNEKS KDVNGPEPLN SRSNKLHFAF RLYDLDKDEK ISRDELLQVL RMMVGVNISD EQLGSIADRT IQEADQDGDS AISFTEFVKV LEKVDVEQKM SIRFLH|
|Molecular Weight||23.5 kDa(210aa), confirmed by MALDI-TOF|
|Form||Liquid, in 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Purity||> 95% by SDS-PAGE|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Shigekawa M., et al. (2001) J Biol Chem. 276(20):17367-72.
Kojima C., et al (2007) J Biol Chem. 282(4):2741-51.
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