CLCF1, 28-225aa, Human

Proteins, Recombinant
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Product Name CLCF1, 28-225aa, Human
Applications SDS-PAGE
Background CLCF1, also known as cardiotrophin-like cytokine factor 1, belongs to the interleukin 6 family of cytokines, which are involved in cell signaling through phosphorylation of gp130. CLCF1 has a sequence of 225-amino acids with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine.
Concentration 0.25 mg/ml (determined by Bradford assay)
Form Liquid, in 50mM Tris-HCl buffer (pH8.0) containing 40% glycerol, 0.15M NaCl, 1mM DTT, 0.1mM PMSF, 1mM MnCl2
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 39.7 kDa (350aa), confirmed by MALDI-TOF
NCBI Accession # NP_037378
Purity > 90% by SDS-PAGE
References Senaldi G., et al. (1999) Proc. Natl. Acad. Sci. U.S.A. 96:11458-11463
Shi Y., et al. (1999) Biochem. Biophys. Res. Commun. 262:132-138
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms Cardiotrophin-like cytokine factor 1, BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6
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