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|Product Name||CLPP, 57-277aa, Human|
|Amino Acid Sequence||MPLIPIVVEQ TGRGERAYDI YSRLLRERIV CVMGPIDDSV ASLVIAQLLF LQSESNKKPI HMYINSPGGV VTAGLAIYDT MQYILNPICT WCVGQAASMG SLLLAAGTPG MRHSLPNSRI MIHQPSGGAR GQATDIAIQA EEIMKLKKQL YNIYAKHTKQ SLQVIESAME RDRYMSPMEA QEFGILDKVL VHPPQDGEDE PTLVQKEPVE AAPAAEPVPA ST|
|Background||CLPP (ATP-dependent Clp protease proteolytic subunit) belongs to the peptidase family S14. CLPP cleaves peptides in various proteins in a process that requires ATP hydrolysis. CLPP, the catalytic core of the Clp proteolytic complex, is widely involved in many cellular processes via the regulation of intracellular protein quality. CLPP may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Recombinant human CLPP protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||0.5mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 100mM NaCl|
|Intended Use||For Research Use Only|
|Molecular Weight||57.0kDa (496aa)|
|NCBI Accession #||NP_006003|
|Purity||> 90% by SDS-PAGE|
|References||Li XH., et al (2010) BMC Microbiol. 19;10:54.
Kang, S.G., et al (2002) J. Biol. Chem. 277: 21095-21102.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Putative ATP-dependent Clp protease proteolytic subunit mitochondrial, Endopeptidase Clp|
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