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|Product Name||COPS8, 1-209aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MPVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGILE QGWQADSTTR MVLPRKPVAG ALDVSFNKFI PLSEPAPVPP IPNEQQLARL TDYVAFLEN|
|Background||COP9 signalosome complex subunit 8 isoform 1, also known as COPS8, is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Recombinant human COPS8 protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Concentration||0.5mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 100mM NaCl|
|Intended Use||For Research Use Only|
|Molecular Weight||53.8kDa (484aa)|
|NCBI Accession #||NP_006701|
|Purity||> 90% by SDS-PAGE|
|References||Lyapina S., et al. (2001) Science. 292:1382-5.
Bech Otschir D., et al. (2001) EMBO J. 20:1630-9.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||COP9 signalosome complex subunit 8, COP9, CSN8, SGN8|
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