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|Product Name||CTNNBIP1, 1-81aa, Human|
|Background||CTNNBIP1 binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. This protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. Recombinant human CTNNBIP1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography|
|Synonyms||ICAT, Beta-catenin-interacting protein 1, Beta catenin interacting protein1, Beta catenin interacting protein ICAT, Catenin beta interacting protein 1, CTNNBIP 1, ICAT, Inhibitor of beta catenin and Tcf 4, MGC15093|
|AA Sequence||MGSSHHHHHH SSGLVPRGSH MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q|
|Molecular Weight||18.9 kDa(173aa), confirmed by MALDI-TOF|
|Form||Liquid, in 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Purity||> 90% by SDS-PAGE|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Tago K., et al. (2000) Genes Dev. 14 (14): 1741-9.
Daniels D.L., et al. (2002) Mol Cell 10:573-584
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