CXCL16 [4.4] Monoclonal Antibody

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Product Name CXCL16 [4.4] Monoclonal Antibody
Description CXCL16, a newly discovered CXC chemokine, exists both in a transmembrane and a soluble form. The membrane bound chemokine act as a ligand for CXC chemokine receptor (CXCR) 6 which is expressed by peripheral blood leukocytes. This membrane-bound CXCL16 is expressed in antigen-presenting cells such as monocytes, macrophages, B cells and dendritic cells in the T-cell zone of lymph nodes, whereas the soluble CXCL16 can be produced by constitutive cleavage from the cell membrane. In addition, CXCL16 expression has been associated with a number of human inflammatory diseases including rheumatoid arthritis, interstitial lung diseases, atherosclerosis, coronary artery disease and liver injury.
Background CXCL16, a newly discovered CXC chemokine, exists both in a transmembrane and a soluble form. The membrane bound chemokine act as a ligand for CXC chemokine receptor (CXCR) 6 which is expressed by peripheral blood leukocytes. This membrane-bound CXCL16 is expressed in antigen-presenting cells such as monocytes, macrophages, B cells and dendritic cells in the T-cell zone of lymph nodes, whereas the soluble CXCL16 can be produced by constitutive cleavage from the cell membrane. In addition, CXCL16 expression has been associated with a number of human inflammatory diseases including rheumatoid arthritis, interstitial lung diseases, atherosclerosis, coronary artery disease and liver injury.
Host Mouse
Clone 4.4
Isotype IgG1
Immunogen GST-CXCL16 (143-224aa) fusion protein
Target C-X-C motif chemokine 16
Reactivity Human
Applications IF, WB
Intended Use For Research Use Only

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