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|Product Name||DCUN1D1, 1-259aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MNKLKSSQKD KVRQFMIFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL DRKKLEQLYN RYKDPQDENK IGIDGIQQFC DDLALDPASI SVLIIAWKFR AATQCEFSKQ EFMDGMTELG CDSIEKLKAQ IPKMEQELKE PGRFKDFYQF TFNFAKNPGQ KGLDLEMAIA YWNLVLNGRF KFLDLWNKFL LEHHKRSIPK DTWNLLLDFS TMIADDMSNY DEEGAWPVLI DDFVEFARPQ IAGTKSTTV|
|Background||DCUN1D1, also known as DCN1-like protein 1, is involved in the malignant transformation of squamous cell lineage. This protein regulates Gli1, a key regulator of the hedgehog (HH) pathway that plays an important role in development, maintenance, and regeneration of almost all adult tissues. Recombinant human DCUN1D1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Concentration||1.0 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.1M NaCl, 1mM DTT|
|Intended Use||For Research Use Only|
|Molecular Weight||19.2 kDa (170aa), confirmed by MALDI-TOF|
|NCBI Accession #||NP_065691|
|Purity||> 90% by SDS-PAGE|
|References||Estilo C.L., et al. (2003). Clin. Cancer Res, 9: 2300-2306.
Lum L., et al. (2004). Science., 304: 1755-1759.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||DCN1-like protein 1, DCUN1L1, RP42, SCCRO, SCRO, Tes3|
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