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|Product Name||DCXR, 1-244aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC|
|Background||Dicarbonyl/L-xylulose reductase, also known as DCXR, is an enzyme responsible for the metabolism of xylulose, converting it into xylitol. DCXR was expressed at low levels and was localized predominantly in the cytoplasmic membrane. In contrast, in virtually all grades of early-stage prostate cancer and in all chemohormonally treated cases, DCXR was strikingly overexpressed and was localized predominantly in the cytoplasm and nucleus. Recombinant human DCXR, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol 1mM DTT, 0.1M NaCl, and 1mM EDTA|
|Intended Use||For Research Use Only|
|Molecular Weight||38.2 kDa (353aa) confirmed by MALDI-TOF|
|NCBI Accession #||NP_057370|
|Purity||> 95% by SDS-PAGE|
|References||Cho Veqa JH., et al. (2007) Cancer Epidemiol Biomakers Prev. 16(12):2615-22.
Nakaqawa J., et al. (2002) J Biol Chem. 277(20):17883-91.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||DCR, HCR2, HCRII, KIDCR, P34H, Dicarbonyl/L-xylulose reductase, L-xylulose reductase, XR, Kidney dicarbonyl reductase, kiDCR, Carbonyl reductase II, Sperm surface protein P34H,|
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