| Product Name | ERp57 Antibody: APC |
|---|---|
| Description | ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glycosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface (6). ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus (7). Mouse Anti-Human ERp57 Monoclonal IgG2b |
| Synonyms | ERp60 Antibody, ERp61 Antibody, Grp57 Antibody, Grp58 Antibody, P58 Antibody, PDIA3 Antibody, PI PLC Antibody, 58 kDa glucose regulated protein Antibody, 58 kDa glucose-regulated protein Antibody, 58 kDa microsomal protein Antibody, Disulfide isomerase ER |
| Host | Mouse |
| Clone | 4F9 |
| Immunogen | Human recombinant ERp57 (Grp58) protein corresponding to amino acids 25 - 505 (his-tagged) |
| Isotype | IgG2b |
| Specificity | Detects ~57 kDa protein. |
| Reactivity | Human |
| Applications | ICC, IF, WB |
| Form | Purified, in PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide |
| Gene Id | NP_005304.3. 2923 |
| Uniprot | P30101 |
| Supplier | Stressmarq Biosciences |
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