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|Product Name||FHIT, 1-147aa, Human|
|Amino Acid Sequence||MSFRFGQHLI KPSVVFLKTE LSFALVNRKP VVPGHVLVCP LRPVERFHDL RPDEVADLFQ TTQRVGTVVE KHFHGTSLTF SMQDGPEAGQ TVKHVHVHVL PRKAGDFHRN DSIYEELQKH DKEDFPASWR SEEEMAAEAA ALRVYFQLEH HHHHH|
|Background||FHIT (fragile histidine triad) is an enzyme that cleaves adenosine 5' PPP 5' A to yield AMP and ADP. FHIT gene encompasses the common fragile site FRA3B on chromosome 3. Alterations and deletions of the FHIT gene are strongly linked to the genesis and establishment of human tumors of the lung, cervix, breast, colon, stomach and pancreas. In normal cells, FHIT may act as a tumor suppressor. This protein physically associates with ubiquitin conjugating enzyme 9. Recombinant human FHIT, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Concentration||0.5mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 1mM EDTA, 50mM NaCl|
|Intended Use||For Research Use Only|
|Molecular Weight||40.5 kDa (362aa), confirmed by MALDI-TOF|
|NCBI Accession #||NP_002003|
|Purity||> 95% by SDS-PAGE|
|References||Kmiec Z., et al. (2009) J Physiol Pharmacol. 60(4):63-70.
Ahmad F., et al. (2010) J Cancer Res Clin Oncol. 136(3):333-50.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Bis (5'-adenosyl)-triphosphatase, AP3Aase, Fragile histidine triad protein AP3A hydrolase, AP3A hydrolase fragile site 3p14.2, Bis 5' adenosyl triphosphatase, Diadenosine 5' 5''' P1 P3 triphosphate hydrolase, Dinucleosidetriphosphatase, FRA 3B, FRA3B, Fragile histidine triad, Fragile histidine triad gene, Fragile histidine triad protein, Tumor suppressor protein.|
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