FIG4/SAC3 Antibody

Category: Antibodies
Catalog
SMC-468D
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Product Name FIG4/SAC3 Antibody
Description Fig4/Sac3 phosphatase, a 97-kDa protein, specifically removes the 5-phosphate from the inositol ring of PI(3,5)P2, a membrane-bound phospholipid, which acts as a molecular signal for trafficking and fusion of intracellular vesicles. It is broadly expressed in all eukaryotic cells and plays a vital role in intracellular membrane trafficking and signaling. Mutations in Fig4/Sac3 have been linked to pale tremor mice that exhibit neuropathy with severe central and peripheral neuronal degeneration, including the loss of neurons in the dorsal root ganglion and the sciatic nerve. Fig4/Sac3 knockout mice have been shown to be smaller in size and exhibit abnormal tremor and gait and neuronal autophagy. . Mouse Anti-Mouse FIG4/SAC3 Monoclonal IgG1
Synonyms Polyphosphoinositide phosphatase Antibody, 5-bisphosphate 5-phosphatase Antibody, Fig4 Antibody, KIAA0274 Antibody, Sac3 Antibody, Phosphatidylinositol 3 Antibody, Phosphatidylinositol 3,5 bisphosphate 5 phosphatase Antibody, SAC domain containing protein
Host Mouse
Clone S202-7
Immunogen Fusion protein amino acids 688-907 (C-terminus) of mouse Sac3. Rat: 95% identity (203/220 amino acids identical). Human: 91% identity (201/220 amino acids identical)
Isotype IgG1
Specificity Detects ~100kDa.
Reactivity Human, Mouse, Rat
Applications ICC, IF, IHC, WB
Form Purified, in PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Gene Id NP_598760.1. 103199
Uniprot Q91WF7
Supplier Stressmarq Biosciences

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