| Product Name | Fish Tumor Necrosis Factor Alpha (TNF-a) ELISA Kit |
|---|---|
| Description | TNFa is synthesized as a 26 kDa, type II transmembrane protein that is 233 amino acids in length. It contains a 30 amino acid (aa) cytoplasmic domain, a 26 aa transmembrane segment, and a 177 aa extracellular region. TNFa is assembled intracellularly to form a transmembrane, non-covalently-linked homotrimeric protein. The 157 aa residue soluble form of TNFa (sTNF-_is released from the C-terminus of the transmembrane protein through the activity of TNFa-converting enzyme (TACE), a membrane -bound disintegrin metalloproteinase. Rat cells known to express TNF-_include B cells, colonic columnar epithelial cells, NK and CD3 CD56 hepatic natural T cells, macrophages, monocytes and monocyte-derived dendritic cells, CD4 and CD8 T cells, mast cells, neutrophils, keratinocytes, plasma cells, and adipocytes. This assay has high sensitivity and excellent specificity for detection of Fish TNF-alpha. No significant cross-reactivity or interference between Fish TNF-_ and analogues was observed. |
| Method | Sandwich ELISA |
| Detection Range | 7.8-500 pg/mL |
| Sensitivity | 3.7 pg/mL |
| Reactivity | Fish |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Supplier | Abebio |
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