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|Product Name||FKBP1a /FKBP12, 1-108aa, Human, Recombinant|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE|
|Background||FK506 binding protein 1a, also known as FKBP12, belongs to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. Recombinant human FKBP12, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Endotoxin Level||< 1.0 EU per 1 microgram of protein (determined by LAL method)|
|Form||Liquid, in 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl 20% glycerol.|
|Intended Use||For Research Use Only|
|Molecular Weight||35.9 kDa (328aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)|
|NCBI Accession #||NP_463460|
|Purity||> 95% by SDS-PAGE|
|References||Jayaraman T., et al. (1992). J Biol Chem. 267(14):9474-7
Siekierka JJ., et al. (1990). J Biol Chem. 265(34):21011-5
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||PPIase FKBP1A, Rotamase, FKBP1, PKC12, FK506 binding protein 1a, 12kDa 12 kDa FKBP, FK506 binding protein 1, FK506 binding protein 1A 12kDa, Immunophilin FKBP12, FK506 binding protein T cell 12 kD, FK506-binding protein 1A, FK506 binding protein 12, FKBP 12, FKBP 1A, FKBP12, FKBP12 Exip3, FKBP12C, Peptidyl-prolyl cis-trans isomerase, PKCI2, PPIase, Protein kinase C inhibitor 2.|
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