FKBP1a /FKBP12, 1-108aa, Human, Recombinant

Proteins, Recombinant
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Product Name FKBP1a /FKBP12, 1-108aa, Human, Recombinant
Applications SDS-PAGE
Background FK506 binding protein 1a, also known as FKBP12, belongs to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. Recombinant human FKBP12, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Concentration 0.5 mg/ml (determined by Bradford assay)
Endotoxin Level < 1.0 EU per 1 microgram of protein (determined by LAL method)
Form Liquid, in 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl 20% glycerol.
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 35.9 kDa (328aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
NCBI Accession # NP_463460
Purity > 95% by SDS-PAGE
References Jayaraman T., et al. (1992). J Biol Chem. 267(14):9474-7
Siekierka JJ., et al. (1990). J Biol Chem. 265(34):21011-5
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms PPIase FKBP1A, Rotamase, FKBP1, PKC12, FK506 binding protein 1a, 12kDa 12 kDa FKBP, FK506 binding protein 1, FK506 binding protein 1A 12kDa, Immunophilin FKBP12, FK506 binding protein T cell 12 kD, FK506-binding protein 1A, FK506 binding protein 12, FKBP 12, FKBP 1A, FKBP12, FKBP12 Exip3, FKBP12C, Peptidyl-prolyl cis-trans isomerase, PKCI2, PPIase, Protein kinase C inhibitor 2.

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