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|Product Name||Frataxin, 42-210aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MLRTDIDATC TPRRASSNQR GLNQIWNVKK QSVYLMNLRK SGTLGHPGSL DETTYERLAE ETLDSLAEFF EDLADKPYTF EDYDVSFGSG VLTVKLGGDL GTYVINKQTP NKQIWLSSPS SGPKRYDWTG KNWVYSHDGV SLHELLAAEL TKALKTKLDL SSLAYSGKDA|
|Background||Frataxin, also known as FXN, is an iron binding protein which belongs to FRATAXIN family. It is an anti-apoptotic protein which prevents mitochondrial damage, reactive oxygen species production and act as either an iron chaperone or an iron storage protein. Frataxin is localized to the mitochondrion and regulating mitochondrial iron transport and respiration. Defects in this protein cause Friedreich ataxia. Recombinant Frataxin protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT 10% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||25.6 kDa (222aa), confirmed by MALDI-TOF.|
|NCBI Accession #||NP_000135|
|Purity||> 95% by SDS-PAGE|
|References||Campuzano V., et al. (1996) Science. 271(5254):1423-7.
Shan Y., et al. (2007) Hum Mol Genet. 16(8):929-41.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||CyaY, FA, FARR, FRDA, X25, FXN, Friedreich ataxia protein.|
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