| Product Name | GADD45G, 1-159aa, Human, Recombinant |
|---|---|
| Description | GADD45G is a member of GADD45 family (GADD45alpha, beta, and gamma) that are nuclear proteins to interact with various proteins implicated in stress responses and cell-cycle-related proteins. The function of GADD45 proteins is involved in growth-regulatory mechanisms and apoptosis. GADD45G protein responds to environmental stresses by mediating activation of p38/JNK pathway via MTK1/MEKK4 kinase and its transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. Recombinant GADD45G protein was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | CR6, DDIT2, Growth arrest and DNA-damage-inducible gamma, Growth arrest and DNA-damage-inducible gamma, Cytokine responsive protein CR6, GADD45G, Growth arrest and DNA damage inducible gamma, GRP17 |
| Host | E.coli |
| Molecular Weight | 21kDa (183aa), confirmed by MALDI-TOF. |
| Amino Acid Sequence | MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris pH 7.5, 1mM DTT, 10% glycerol |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
| References |
Takekawa M., et al. (1998) Cell 95(4), 521-30 Zerbini LF., et al. (2004) PNAS 101(37), 13618-23 |
| Supplier | ARP |
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