GIMAP5, 1-284aa, Human

Category: Proteins
Catalog
01-P2319
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Product Name GIMAP5, 1-284aa, Human
Description GIMAP5 is a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. GIMAP5 is an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. Recombinant human GIMAP5 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms GTPase IMAP family member 5, HIMAP3, IAN-5, IAN4, IAN4L1, IAN5, IMAP3, IROD
Host E.coli
Molecular Weight 19.6 kDa (186aa) confirmed by MALDI-TOF
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSMGGFQRG KYGTMAEGRS EDNLSATPPA LRIILVGKTG CGKSATGNSI LGQPVFESKL RAQSVTRTCQ VKTGTWNGRK VLVVDTPSIF ESQADTQELY KNIGDCYLLS APGPHVLLLV IQLGRFTAQD TVAIRKVKEV FGTGAMRHVV ILFTHKEDLG GQALDDYVAN TDNCSLKDLV RECERRYCAF NNWGSVEEQR QQQAELLAVI ERLGREREGS FHSNDLFLDA QLLQRTGAGA CQEDYRQYQA KVEWQVEKHK QELRENESNW AYKALLRVKH LMLLHYE
Tag His-tag
Reactivity Human
Applications SDS-PAGE
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
Concentration 1 mg/ml (determined by Bradford assay)
Purity > 85% by SDS-PAGE
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
References Wong V.W., et al. (2010) Self/Nonself. 1:259-268
Ota T., et al. (2004) Nat. Genet. 36:40-45
Supplier ARP

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