GIP, 22-153aa, Human His tag

Proteins, Recombinant
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Product Name GIP, 22-153aa, Human His tag
Applications SDS-PAGE
Background GIP, also known as glucose-dependent insulinotropic polypeptide, is an important insulin-releasing hormone of the enteroinsular axis that has a functional profile of possible therapeutic value for type 2 diabetes. This protein is an important incretin hormone released into the circulation from endocrine K-cells of the duodenum and jejunum after ingestion of food1. It was evaluated for their ability to elevate cellular cAMP production and stimulate insulin secretion. It also promotes plasma triglyceride clearance in response to oral fat loading. In liver, GIP has been shown to enhance insulin-dependent inhibition of glycogenolysis. Recombinant human GIP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Concentration 0.25 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 41.5 kDa (373aa) confirmed by MALDI-TOF
NCBI Accession # AAH69100
Purity > 90% by SDS-PAGE
References O'Harte FP. et al. (1999) Diabetes. 48:758-765
Gault VA. et al. (2002) Biosci Rep. 22:523-528.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms Gastric inhibitory polypeptide, Glucose-dependent insulinotropic polypeptide, Gastric Inhibitory Peptide
Tag His-tag

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