GMPR2, 1-348aa, Human

Catalog
01-2384-1
$0.00
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Proteins, Recombinant
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More Information
Product Name GMPR2, 1-348aa, Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC
Applications SDS-PAGE
Background Guanosine monophosphate reductase 2, also known as GMPR2, is the only known metabolic step by which guanine nucleotides can be converted to the pivotal precursor of both adenine and guanine nucleotides. GMPR2 catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP, and plays a critical role in re-utilization of free intracellular bases and purine nucleosides. Recombinant human GMPR2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 14.1 kDa (124aa), confirmed by MALDI-TOF
NCBI Accession # NP_001002002
Purity > 90% by SDS-PAGE
References Li J., et al. (2006) J Mol Biol. 355(5):980-8.
Denq Y., et al. (2002) Int J Biochem Cell Biol. 34(9):1035-50.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms Guanosine monophosphate reductase 2, GMP reductase 2, Guanosine 5'-monophosphate oxidoreductase 2
Tag His-tag

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