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|Product Name||GOT1, 1-413aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MAPPSVFAEV PQAQPVLVFK LTADFREDPD PRKVNLGVGA YRTDDCHPWV LPVVKKVEQK IANDNSLNHE YLPILGLAEF RSCASRLALG DDSPALKEKR VGGVQSLGGT GALRIGADFL ARWYNGTNNK NTPVYVSSPT WENHNAVFSA AGFKDIRSYR YWDAEKRGLD LQGFLNDLEN APEFSIVVLH ACAHNPTGID PTPEQWKQIA SVMKHRFLFP FFDSAYQGFA SGNLERDAWA IRYFVSEGFE FFCAQSFSKN FGLYNERVGN LTVVGKEPES ILQVLSQMEK IVRITWSNPP AQGARIVAST LSNPELFEEW TGNVKTMADR ILTMRSELRA RLEALKTPGT WNHITDQIGM FSFTGLNPKQ VEYLVNEKHI YLLPSGRINV SGLTTKNLDY VATSIHEAVT KIQ|
|Background||Glutamic-oxaloacetic transaminase (GOT) is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Recombinant human GOT1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||16.6 kDa(147aa), confirmed by MALDI-TOF|
|NCBI Accession #||NP_002070|
|Purity||> 95% by SDS-PAGE|
|References||Bousquet-Lemercier B., et al. (1990) Biochemistry 29 (22): 5293-9.
Totan A., et al. (2006) Clin Chem Lab Med. 44(5):612-5.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Aspartate aminotransferase 1, Transaminase A, GIG18, Glutamic-oxaloacetic transaminase 1, Aspartate aminotransferase cytoplasmic, GIG 18, GIG18, Glutamate oxaloacetate transaminase1, Glutamic oxaloacetic transaminase 1 soluble, GOT 1, Growth inhibiting protein 18, SGOT, Transaminase,|
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