| Product Name | GRK (pan) Antibody: APC |
|---|---|
| Description | G protein-coupled receptor kinases (GRK) are serine/threonine kinases that phosphorylate a variety of G-protein-coupled receptors (GPCRs), specifically activated forms, including adrenergic receptors, muscarinic acetylcholine receptors, dopamine receptors and opioid receptors. GRK receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Mouse Anti-Mouse GRK (pan) Monoclonal IgG1 |
| Synonyms | G protein-coupled receptor kinase Antibody, Pan-GRK Antibody, GRK-pan Antibody, GRK Antibody, Antibody |
| Host | Mouse |
| Clone | S145-20 |
| Immunogen | Fusion protein amino acids 381-590 (C-terminus) of mouse GRK5. 91% identical to human, and 99% identical to rat. >55% identity with GRK6 and GRK4. >40% identity with GRK7 and RK. |
| Isotype | IgG1 |
| Specificity | Detects 70kDa. Cross-reacts with GRK6. |
| Reactivity | Human, Mouse, Rat |
| Applications | ICC, IF, WB |
| Form | Purified, in PBS pH 7.4, 50% glycerol, 0.1% sodium azide |
| Gene Id | NP_061357.3. 14773 |
| Uniprot | Q8VEB1 |
| Supplier | Stressmarq Biosciences |
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