Grp75 Antibody: ATTO 700

Category: Antibodies
Catalog
SMC-133D-A700
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Product Name Grp75 Antibody: ATTO 700
Description Grp75, also known as mortalin, is a member of HSP70 family of chaperone proteins that is not heat inducible (1, 2). Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with HSP60 in the re-folding of proteins translocated into this organelle (3, 4). Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53 (5). Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation (6). Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts (7). And finally, like its E.coli homolog DnaK (8), GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone (9, 10). Mouse Anti-Mouse Grp75 Monoclonal IgG1
Synonyms HSC74 Antibody, HSP74 Antibody, HSPA9 Antibody, HSPa9a Antibody, HSPA9B Antibody, Mortalin 2 Antibody, MOT2 Antibody, PBP74 Antibody, 75 kDa glucose regulated protein antibody, 75 kDa glucose-regulated protein antibody, CSA antibody, Glucose Regulated Pro
Host Mouse
Clone S52A-42
Immunogen Fusion protein amino acids 551-766 of mouse SALM2.
Isotype IgG1
Specificity Detects ~75kDa.
Reactivity Human, Mouse, Rat, Parasite
Applications ELISA, ICC, IF, IHC, IP, WB
Form Purified, in PBS pH7.2, 50% glycerol, 0.09% sodium azide
Gene Id NP_004125.3. 3313
Uniprot P38646
Supplier Stressmarq Biosciences

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