GRP78 Antibody: ATTO 488

Category: Antibodies
Catalog
SMC-211D-A488
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Product Name GRP78 Antibody: ATTO 488
Description GRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1). GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3). In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer's patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7). . Mouse Anti-Rat GRP78 Monoclonal IgG1 Kappa
Synonyms 78 kDa glucose regulated protein Antibody, 78 kDa glucose-regulated protein Antibody, AL022860 Antibody, AU019543 Antibody, BIP Antibody, D2Wsu141e Antibody, D2Wsu17e Antibody, Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 Antibody, Endoplasm
Host Mouse
Clone 3G12-1G11
Immunogen Full-length recombinant rat GRP78
Isotype IgG1 kappa
Specificity Detects ~78kDa.
Reactivity Human, Mouse, Rat
Applications ELISA, ICC, IF, WB
Form Purified, in PBS pH7.4, 50% glycerol, 0.09% sodium azide
Gene Id NP_037215.1. 25617
Uniprot P06761
Supplier Stressmarq Biosciences

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