GRP94 Antibody: ATTO 680

Category: Antibodies
Catalog
SMC-105B-A680
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Product Name GRP94 Antibody: ATTO 680
Description Grp94 (glucose regulated protein 94, gp96) is a constitutively expressed endoplasmic reticulum (ER) lumenal protein that is up-regulated in response to cellular stress such as heat shock, oxidative stress or glucose depletion. Grp94 is thought to play a role in protein translocation to the ER, in their subsequent folding and assembly, and in regulating protein secretion (1). Grp94 also plays a role in antigen presentation by accessing the endogenous pathway and eliciting specific CTL responses to chaperone bound peptides via MHC class I pathway (2). Grp94 is a member of the HSP90 family of stress proteins and shares sequence homology with its cytosolic equivalent, HSP90 (3). Both HSP90 and Grp94 are calcium binding proteins (4). Despite sharing 50% sequence homology over its N domains and complete conservation in its ligand binding domains with HSP90, Grp94 and HSP90 differ in their interactions with regulatory ligands as Grp94 has weak ATP binding and hydrolysis activity (5). Grp94 exists as a homodimer and the two subunits interact at two distinct intermolecular sites, C terminal dimerization domains and the N-terminal interacts with the middle domain of opposing subunits (6). Grp94 contains a carboxy terminal KDEL (Lys-Asp-Glu-Leu) sequence which is believed to aid in its retention in the ER (7). Rat Anti-Chicken GRP94 Monoclonal IgG2a
Synonyms HSP90B1 Antibody, GP96 Antibody, TRA1 Antibody, ECGP Antibody, 94 kDa glucose regulated protein antibody, 94 kDa glucose-regulated protein antibody, ECGP antibody, Endoplasmin antibody, Endothelial cell (HBMEC) glycoprotein antibody, ENPL_HUMAN antibody,
Host Rat
Clone 9G10
Immunogen Purified Grp94 isolated from chicken oviducts
Isotype IgG2a
Specificity Detects ~98kDa. Does not detect human HSP90, Grp74, or GrpE from E.coli.
Reactivity Amphibian, Bovine, Canine, Chicken, Equine, Guinea Pig, Hamster, Human, Mouse, Porcine, Primate, Rabbit, Rat, Sheep
Applications FCM, ICC, IF, IP, WB
Form Purified, in PBS pH7.2, 50% glycerol, 0.09% sodium azide
Gene Id NP_003290.1. 7184
Uniprot P14625
Supplier Stressmarq Biosciences

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