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|Product Name||HBXIP, 1-173aa Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSHMEPGAG HLDGHRAGSP SLRQALCDGS AVMFSSKERG RCTVINFVPL EAPLRSTPRS RQVTEACGGE GRAVPLGSEP EWSVGGMEAT LEQHLEDTMK NPSIVGVLCT DSQGLNLGCR GTLSDEHAGV ISVLAQQAAK LTSDPTDIPV VCLESDNGNI MIQKHDGITV AVHKMAS|
|Background||Hepatitis B virus x interacting protein, also known as HBXIP, was originally identified by its ability to form a complex with the C-terminus of hepatitis B virus X (HBX) protein. HBXIP negatively regulates the activity of HBX and alters the replicative life cycle of the virus. In addition, HBXIP is involved in bipolar spindle formation and regulates centrosome dynamics and cytokinesis in cells, possibly through an interaction with Dynein light chain. Recombinant human HBXIP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.15M NaCl|
|Intended Use||For Research Use Only|
|Molecular Weight||27.6kDa(246aa), confirmed by MALDI-TOF
(Molecular size on SDS-PAGE will appear higher)
|NCBI Accession #||NP_006393|
|Purity||> 90% by SDS-PAGE|
|References||Zhang X., et al. (2005) J Med Virol. 77: 374-381
Melegari M., et al. (1998) J Virol. 72: 1737-1743.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Hepatitis B virus x interacting protein, XIP|
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