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|Product Name||HEXIM1, 1-359aa, Human|
|Background||HEXIM1 is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This protein has been shown to form a protein-RNA complex composed of 7SK small nuclear RNA and positive transcription elongation factor b (P-TEFb), which is composed of cyclin-dependent kinase 9 (CDK9) and cyclin T1, and to inhibit the kinase activity of CDK9, thereby suppressing RNA polymerase II-dependent transcriptional elongation. Recombinant HEXIM1 protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||CLP1, EDG1, HIS1, MAQ1, Hexamethylene bis-acetamide inducible 1 Cardiac lineage protein 1, CLP 1, EDG 1, FLJ13562, Hexamethylene bis acetamide inducible 1, Hexamethylene bis acetamide inducible protein, Hexamethylene bis acetamide inducible transcript 1, HEXIM 1, HEXIM1 protein, HIS 1, HMBA inducible, MAQ 1, Menage a quatre 1.|
|AA Sequence||MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMAE PFLSEYQHQP QTSNCTGAAA VQEELNPERP PGAEERVPEE DSRWQSRAFP QLGGRPGPEG EGSLESQPPP LQTQACPESS CLREGEKGQN GDDSSAGGDF PPPAEVEPTP EAELLAQPCH DSEASKLGAP AAGGEEEWGQ QQRQLGKKKH RRRPSKKKRH WKPYYKLTWE EKKKFDEKQS LRASRIRAEM FAKGQPVAPY NTTQFLMDDH DQEEPDLKTG LYSKRAAAKS DDTSDDDFME EGGEEDGGSD GMGGDGSEFL QRDFSETYER YHTESLQNMS KQELIKEYLE LEKCLSRMED ENNRLRLESK RLGGDDARVR ELELELDRLR AENLQLLTEN ELHRQQERAP LSKFGD|
|Molecular Weight||30.5 kDa (264aa), confirmed by MALDI-TOF.|
|Form||Liquid, in 20mM Tris buffer (pH 8.0) containing 10% glycerol 1mM DTT.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Purity||> 90% by SDS-PAGE|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Shimizu N., et al. (2005) Proc. Natl. Acad. Sci. U.S.A. 102(24):8555-60
Li Q., et al. (2007) Nucleic Acids Res 35(8):2503-12.
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