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|Product Name||HOXA9, 1-272aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMATTGAL GNYYVDSFLL GADAADELSV GRYAPGTLGQ PPRQAATLAE HPDFSPCSFQ SKATVFGASW
NPVHAAGANA VPAAVYHHHH HHPYVHPQAP VAAAAPDGRY MRSWLEPTPG ALSFAGLPSS RPYGIKPEPL SARRGDCPTL DTHTLSLTDY
ACGSPPVDRE KQPSEGAFSE NNAENESGGD KPPIDPNNPA ANWLHARSTR KKRCPYTKHQ TLELEKEFLF NMYLTRDRRY EVARLLNLTE
RQVKIWFQNR RMKMKKINKD RAKDE
|Background||HOXA9 belongs to the Abd-B homeobox family. This protein is a transcription factor with a central role in both haemopoiesis and leukaemia. High levels of HOXA9 expression in haemopoietic cells is a characteristic feature of acute myeloid leukaemia (AML), and may be sufficient to cause this disease. Overexpression of Hoxa 9 markedly expands hematopoietic stem cells. Recombinant human HOXA9 protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||33.9 kDa (300aa)|
|NCBI Accession #||NP_689952|
|Purity||> 85% by SDS-PAGE|
|References||Bandyopadhyay S., et al. (2012) Mol. Cell. Biol. 32:1202-1213
Patel C.V., et al. (1999) J. Biol. Chem. 274:1415-1422
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Homeobox protein Hox-A9, ABD-B, HOX1, HOX1.7, HOX1|
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