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|Product Name||HPCAL1, 1-193aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF|
|Background||HPCAL1, also known as VILIP-3, is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It is involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Recombinant human HPCAL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT, 50mM NaCl|
|Intended Use||For Research Use Only|
|Molecular Weight||34.4kDa (316aa), confirmed by MALDI-TOF|
|NCBI Accession #||NP_002140|
|Purity||> 95% by SDS-PAGE|
|References||Fu J., et al. (2009) J Biol Chem. 284(40):27577-86.
Spilker C., et al. (2003) Mol Cell Neurosci. 24(3):766-78.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Hippocalcin-like 1, BDR1, Calcium-binding protein BDR-1, Hippocalcin-like protein 1, HLP2, VILIP-3, visinin-like protein 3, VILIP3|
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