HSD17B10, 12-261aa, Human

Proteins, Recombinant
More Information
Product Name HSD17B10, 12-261aa, Human
Applications SDS-PAGE
Background HSD17B10 is a member of the short-chain dehydrogenase/reductase superfamily. This mitochondrial protein catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. HSD17B10 plays an important role in processing steroid hormones and fats, and also helps break down the protein building block (amino acid) isoleucine. This enzyme is also necessary for several chemical reactions involving female sex hormones (estrogens) and male sex hormones (androgens). It is essential for maintaining appropriate levels of male and female sex hormones. This protein may contribute to the neuronal dysfunction associated with Alzheimer disease. Recombinant HSD17B10 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
Species Human
Host Hi-5
Intended Use For Research Use Only
Molecular Weight 28.8kDa (255aa), confirmed by MALDI-TOF.
NCBI Accession # NP_004484
Purity > 95% by SDS-PAGE
References Hoizmann J., et al. (2008) Cell. 135(3):462-74.
Yan SD., et al. (1997) Nature. 389(6652):689-95.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms Hydroxyacyl Coenzyme A dehydrogenase type II, Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase, 17 beta hydroxysteroid dehydrogenase 10, 17 beta hydroxysteroid dehydrogenase type 10, 17b HSD10, 3 hydroxy 2 methylbutyryl CoA dehydrogenase, 3 hydroxyacyl CoA dehydrogenase type 2, 3 hydroxyacyl CoA dehydrogenase type II, AB binding alcohol dehydrogenase, ABAD, Ads9, Amyloid beta binding polypeptide, Amyloid beta peptide binding alcohol dehydrogenase, Amyloid beta peptide binding protein, CAMR, DUPXp11.22, Endoplasmic Reticulum Amyloid Binding Protein, Endoplasmic reticulum associated amyloid beta peptide binding protein, ER associated amyloid beta-binding protein, ERAB, HADH 2, HADH2, HCD 2, HCD2, HSD17B10, Hydroxyacyl CoA Dehydrogenase type II, Hydroxysteroid (17 beta) dehydrogenase 10, Mental retardation X linked syndromic 11, MHBD, Mitochondrial ribonuclease P protein 2, Mitochondrial RNase P protein 2, MRPP2, MRX17, SCHAD, SDR5C1, Short chain dehydrogenase/reductase family 5C member 1, Short chain L 3 hydroxyacyl CoA dehydrogenase type 2, Short chain type dehydrogenase/reductase XH98G2, Type 10 17b HSD, Type 10 17beta hydroxysteroid dehydrogenase, Type II HADH, XH98G2, 3-hydroxyacyl-CoA dehydrogenase type-2
Tag His-tag

All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.

Hi, have questions?

An ARP Customer Service Representative is happy to help!

or Call (800) 832-2611