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|Product Name||HSD17B10, 12-261aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MVAVITGGAS GLGLATAERL VGQGASAVLL DLPNSGGEAQ AKKLGNNCVF APADVTSEKD VQTALALAKG KFGRVDVAVN CAGIAVASKT YNLKKGQTHT LEDFQRVLDV NLMGTFNVIR LVAGEMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIVGMTL PIARDLAPIG IRVMTIAPGL FGTPLLTSLP EKVCNFLASQ VPFPSRLGDP AEYAHLVQAI IENPFLNGEV IRLDGAIRMQ P|
|Background||HSD17B10 is a member of the short-chain dehydrogenase/reductase superfamily. This mitochondrial protein catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. HSD17B10 plays an important role in processing steroid hormones and fats, and also helps break down the protein building block (amino acid) isoleucine. This enzyme is also necessary for several chemical reactions involving female sex hormones (estrogens) and male sex hormones (androgens). It is essential for maintaining appropriate levels of male and female sex hormones. This protein may contribute to the neuronal dysfunction associated with Alzheimer disease. Recombinant HSD17B10 protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||28.8kDa (255aa), confirmed by MALDI-TOF.|
|NCBI Accession #||NP_004484|
|Purity||> 95% by SDS-PAGE|
|References||Hoizmann J., et al. (2008) Cell. 135(3):462-74.
Yan SD., et al. (1997) Nature. 389(6652):689-95.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Hydroxyacyl Coenzyme A dehydrogenase type II, Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase, 17 beta hydroxysteroid dehydrogenase 10, 17 beta hydroxysteroid dehydrogenase type 10, 17b HSD10, 3 hydroxy 2 methylbutyryl CoA dehydrogenase, 3 hydroxyacyl CoA dehydrogenase type 2, 3 hydroxyacyl CoA dehydrogenase type II, AB binding alcohol dehydrogenase, ABAD, Ads9, Amyloid beta binding polypeptide, Amyloid beta peptide binding alcohol dehydrogenase, Amyloid beta peptide binding protein, CAMR, DUPXp11.22, Endoplasmic Reticulum Amyloid Binding Protein, Endoplasmic reticulum associated amyloid beta peptide binding protein, ER associated amyloid beta-binding protein, ERAB, HADH 2, HADH2, HCD 2, HCD2, HSD17B10, Hydroxyacyl CoA Dehydrogenase type II, Hydroxysteroid (17 beta) dehydrogenase 10, Mental retardation X linked syndromic 11, MHBD, Mitochondrial ribonuclease P protein 2, Mitochondrial RNase P protein 2, MRPP2, MRX17, SCHAD, SDR5C1, Short chain dehydrogenase/reductase family 5C member 1, Short chain L 3 hydroxyacyl CoA dehydrogenase type 2, Short chain type dehydrogenase/reductase XH98G2, Type 10 17b HSD, Type 10 17beta hydroxysteroid dehydrogenase, Type II HADH, XH98G2, 3-hydroxyacyl-CoA dehydrogenase type-2|
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