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|Product Name||HSPB7, 1-170aa, Human|
|Background||HSPB7 is a member of HSPB (Heat shock protein beta) family. The HSPB family is one of the more diverse families within the group of HSP families. Some members have chaperone-like activities and/or play a role in cytoskeletal stabilization. Some members also show a dynamic, stress-induced translocation to SC35 splicing speckles. HSPB7 constitutively localized to SC35 splicing speckles, driven by its N-terminus. Unlike HSPB1 and HSPB5, that chaperoned heat unfolded substrates and kept them folding competent, HSPB7 did not support refolding. Recombinant HSPB7 protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||cvHSP, DKFZp779D0968, FLJ32733, Heat shock protein beta-7 cvhsp, Heat shock 27kda protein family member 7, Heat shock protein beta 7, hspb7, Hypothetical protein flj34956.|
|AA Sequence||MGSSHHHHHH SSGLVPRGSH MSHRTSSTFR AERSFHSSSS SSSSSTSSSA SRALPAQDPP MEKALSMFSD DFGSFMRPHS EPLAFPARPG GAGNIKTLGD AYEFAVDVRD FSPEDIIVTT SNNHIEVRAE KLAADGTVMN TFAHKCQLPE DVDPTSVTSA LREDGSLTIR ARRHPHTEHV QQTFRTEIKI|
|Molecular Weight||13.4 kDa (122aa), confirmed by MALDI-TOF.|
|Form||Liquid, in 20mM Tris buffer (pH 8.0) containing 10% glycerol, 1mM DTT.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Purity||> 85% by SDS-PAGE|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||VOS MJ., et al. (2009) Biochim Biophys Acta. 1793(8):1343-53.
Matkovich SJ, et al. (2010) J Clin Invest. 120(1):280-9
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