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|Product Name||IPP-1, 1-171aa, Human, Recombinant|
|Amino Acid Sequence||MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNPHL KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE PEGAAESTGT QESRPPGIPD TEVESRLGTS GTAKKTAECI PKTHERGSKE PSTKEPSTHI PPLDSKGANS VLEHHHHHH|
|Background||Protein phosphatase inhibitor-1(IPP-1) plays an important role in the regulation of glycogen metabolism through inhibition of type-1 protein serine/threonine phosphatase(PP1) activity, and it has been implicated in the regulation of cell growth. IPP-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. In the presence of calcium, PPI-1 is inactivated by calcineurin (or PP2B). Recombinant human IPP-1, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in Phosphate buffer saline (pH 7.4)|
|Intended Use||For Research Use Only|
|Molecular Weight||9kDa (78aa), confirmed by MALDI-TOF.|
|NCBI Accession #||NP_006732|
|Purity||> 90% by SDS-PAGE|
|References||Weiser DC., et al. (2004), J. Biol. Chem. 279(47):48904-14
Rodriguez P., et al. (2006), J. Biol. Chem. 281(50):38599-608
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Protein phosphatase inhibitor, Protein phosphatase inhibitor-1 Protein phosphatase inhibitor 1, I 1, I1, Inhibitor 1, IPP 1, IPP1, PPP1R1A, Protein phosphatase 1 regulatory (inhibitor) subunit 1A, Protein phosphatase 1 regulatory subunit 1A.|
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