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|Product Name||IPP-POZ domain (1-157aa), Human Recombinant|
|Amino Acid Sequence||MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT EVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEF|
|Background||Intracisternal A particle-promoted polypeptide(IPP) is a 66kDa protein(584 amino acids), which contains an N-terminal POZ protein-protein interaction domain and a C-terminla kelch repeat domain consisting of six tandem arranged repeats. The POZ domain(also called BTB domain) is present near the N-terminus of a fraction of zinc finger proteins and in protein that contain the pfam01344 motif such as kelch and pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-coR and SMRT. IPP-POZ domain(1-157aa) was overexpressed in E.coli and purified by using conventional chromatography techniques|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris pH 7.5, 2mM EDTA, 20% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||28 kDa (261 aa), confirmed by MALDI-TOF.|
|NCBI Accession #||NP_005888|
|Purity||> 95% by SDS-PAGE|
|References||Kim IF., et al. (1999) Gene 228(1-2), 73-83.
Chang-Yeh, A., et al. (1993) Genomics. 15(1), 239-241.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||IPP, KLHL27, IPP-POZ domain, MIPP protein, Kelch-like protein 27, Actin-binding protein IPP, Intracisternal A particle-promoted polypeptide isoform 1, Protein phosphatase inhibitor 1, Actin binding protein IPP, I1, Intracisternal A particle promoted polypeptide, IPP POZ, Kelch like protein 27, Protein phosphatase 1 regulatory subunit 1A|
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